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Children who are genetically predisposed to overweight, due to common gene variants, can still lose weight by changing their diet and exercise habits. Around 750 children and adolescents with overweight or obesity undergoing lifestyle intervention participated in the study conducted by researchers from the University of Copenhagen and Holbæk Hospital.
Overweight and obesity constitute an increasing global problem that may lead to serious sequelae such as heart attacks, diabetes and cancer. In 2016, 124 million children and adolescents worldwide suffered from obesity. Now researchers from the University of Copenhagen and the Children's Obesity Clinic, the Department of Paediatrics at Holbæk Hospital have examined how genetics affect children and young people's ability to lose excess weight.
'We are trying to understand the genetic driving force behind overweight and whether this force also makes it impossible for some to lose weight. We show that a high genetic predisposition to overweight during childhood in fact had no influence on whether the children reacted to lifestyle intervention compared to children with low genetic predisposition to overweight. The 15 genetic variants we have studied are common in the population and are the ones that in general increase a child's risk of becoming overweight,' says Postdoc at the Novo Nordisk Foundation Center for Basic Metabolic Research at UCPH Theresia Maria Schnurr, who is one of the authors of the study.
The new research results have just been published in the scientific journal Obesity. The researchers' aim was to determine the influence of specific gene variants on children and adolescents' ability to lose weight. Therefore, they studied the 15 specific gene variants implicated in childhood obesity and which are common in the population. In the study, the researchers demonstrate that these genetic variants did not predict whether children and adolescents' were able to lose weight when they changed their lifestyle. So far only children with a rare genetic mutation in the MC4R gene do not seem to lose weight when undergoing lifestyle intervention.
Lifestyle Intervention Led to Weight Loss
The researchers examined 754 children and adolescents with overweight and obesity. The median age was 11.6 years. The genetic profile of all participants was mapped, and the researchers then calculated a genetic risk score for childhood overweight for each participant based on the 15 genetic variants. They all carried one or more of the 15 genetic variants associated with increased risk for obesity and overweight during childhood. To determine whether a genetic predisposition for overweight affected the children and adolescents' ability to lose weight the children had to implement a series of lifestyle changes.
They followed a treatment protocol developed at Holbæk Hospital. The protocol centres around the family with behavioural lifestyle changes. For example, the children and adolescents had to change their diet, means of transportation, physical activity, sedentary activity, amount of sleep, consumption of snacks and sweet things and social activities. The intervention lasted six to 24 months. Subsequently, the researchers followed up on the treatment and found that the lifestyle changes had affected the weight of the participants, despite their genetic disposition for overweight and obesity.
'Large parts of the population believes that when you have problematic genes it is game over. That is why it is very important we send a clear message that even though you have a genetic sensitivity this treatment can help people. We have discovered that it does not matter whether the children and adolescents have an increased genetic risk score or not. They can respond to treatment just as well. This means our treatment is efficient despite carrying common obesity risk genes. It gives hope to people with obesity and obesity related complications such as high blood pressure, cholesterol and fatty liver that we can in fact help them,' says one of the study's authors Jens-Christian Holm, doctor and head of the Children's Obesity Clinic, Holbæk Hospital.
Genetic Markers
The genetic variants the researchers have examined are common in the population and turned out not to have an effect on the ability to lose weight during the intervention. So far, the researchers did not find any biological markers for a poor response on lifestyle intervention except for the rare gene MC4R associated with poor response in terms of weight loss following a lifestyle intervention.
'MC4R is a rare genetic mutation and thus the question remains why around 75 percent of children in a group of children receiving the exact same treatment react more positively to the treatment compared to the remaining 25 percent of children not responding to lifestyle treatment. Identifying additional common genetic markers would help us understand the biological pathways that affect obesity and a person's reaction to lifestyle changes -- and thus in the long term help us provide even better treatments,' says Professor at the Novo Nordisk Foundation Center for Basic Metabolic Research Torben Hansen, last author of the study.

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I was strict keto from 4/26/18 until around mid November. Lost 20lbs but been in a sorta-intentional maintenance mode for the last month and a half. Now that i’m ready to get back to losing/cutting, I need to get serious this time around about making my body stronger. I have serious posture issues that causes me on and off back pain that i’m getting really tired of. The top half of my back is pretty hunched over in a “resting” position and my lower back is pushed forward (belly sticks out further than it should IMO). My main goal in growing physically stronger is to realign my entire core (back, shoulders, abs).
I’d like to start with body weight exercises first and i’m here to see if anyone has and suggestions for me but please keep in mind that i’m a beginner
Female, 24, CW 155 (keto SW 178)

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The Paleo diet offers many benefits, but can it also save you money in retirement?
It turns out good health really may be like money in the bank.
At age 57, the tide of my health had receded—leaving me high and dry on Obesity Beach.
Despite regular workouts and a “healthy” conventional low-fat, high-fiber diet, I was needlessly fat, hypercholesterolemic, pre-diabetic, constantly ill with colds, flu and digestive issues, always tired, and hungry. I just didn’t know any better.
Increasingly paranoid about heart health, I’d run to the doctor (or even the hospital) at the slightest provocation.
Then, by pure luck (and the temporary theft of someone else’s Christmas present – the book The Whole 30,) I discovered the Paleo lifestyle and diet.
Fast forward to age 60 and I am no longer high and dry. I lost at least 40 pounds, I’ve been through three wardrobes, haven’t seen my GP since 2015, have stopped all meds, and am in better shape than any time since I was 35. Energetic and alert throughout the day, I have at least doubled my productivity.
My long-suffering wife Kathleen is certainly happier and not only with my new svelte look. She also lost weight, improved her health and energy, and gave away bushels of clothes.
Even better, we’ve discovered that over the next 30 years we will likely save thousands, if not hundreds of thousands of dollars.
An unexpected benefit of the diet was that medical practitioners were no longer regulars in our social circle. Even with decent health insurance, a couple dozen doctor visits per year, including testing and the inevitable prescriptions, costs quite a bit.
Because of our healthier lifestyle, we were no longer spending that extra $1,500.00.
This discovery led us to look beyond the up-front Paleo benefits (new physiques, play-all-day energy) and realize that not only were we saving money on routine health care, but we had dramatically increased the odds of avoiding long-term, chronic disease.
Imagine potentially not having to worry about cancer, diabetes, heart disease, arthritis, or even Alzheimer’s (or their shocking costs) as you get older. These conditions (and many others) are so prevalent now, especially in the elderly, that we no longer question their inevitability. Even though our hunter-gatherer ancestors were largely free of these conditions.
Now imagine not having to pay hundreds of thousands of dollars in the last third of your life for expenses directly caused by unhealthy lifestyle and diet.
Back in the 90s, financial planners began to focus on estimated medical expenses as retiree healthcare costs, especially for chronic, long term care, roared into the spotlight.
Today, many planners recommend setting aside $500,000.00 or more for insurance premiums, copays, and non-covered or out of pocket expenses. [1] This figure assumes retirees will have one or more lifelong debilitating conditions and spend at least a couple years in a skilled nursing or assisted living facility.
And, since many pre-retirees can’t qualify for specialized long-term care insurance (the majority already have early “pre-existing” versions of various chronic ailments) – or simply can’t afford the coverage – they usually pay these long term care costs out of pocket.
Many go broke doing so.
A 2018 survey of average annual long-term care (LTC) costs [2] shows a range of $48,000.00 (assisted living) to $100,380.00 (nursing home, private room) to $183,456.00 (24-hour in-home care.)
These expenditures are so distressingly commonplace that financial advisors can’t (and shouldn’t) overlook them. They have to assume you’ll get sick and stay sick.
Most people do.
But do you have to be “most people?”
Because long-term, chronic illness is so pervasive, we don’t realize that it is not inevitable.
For thousands of years, our Paleolithic ancestors enjoyed lives largely free of disease. Current isolated ancestral populations also show the same lack of lifestyle-based illnesses, which are known as “diseases of Western civilization.” [3] [4] These include today’s top killers: diabetes, diabetes type 3 (Alzheimer’s,) cancer, and cardiovascular disease.
Historic or current Ancestral groups have no genetic advantage over us – they simply didn’t (and don’t) spend their lives eating food that would make them sick.
It has repeatedly been shown that when Ancestral populations adopt the Western diet, health declines are precipitous and measurable – and, thankfully, reversible when the population reverts back to hunter-gatherer norms. [5]
Abandoning conventional diet, heavy with refined carbs, trans fats, sky-high levels of omega-6 fatty acids, sugars, seed oils and engineered hyper-palatable processed foods is a tough but necessary first step to reclaiming health.
All these foods promote ongoing intestinal permeability, systemic inflammation and obesity, and are strongly linked to chronic disease. Like me, many westerners have been systemically inflamed for a half century or more. Removing these foods literally allows the body to begin healing itself.
The Paleo Diet focuses on lean meats, starchy and non-starchy vegetables, healthy fats, fruit and nuts. These foods, especially where non-starchy vegetables comprise 60% or more of each meal, by weight, dramatically increase the level of natural, bio-available macro- and micro-nutrients your body needs to accelerate the healing process.
Instead of wearily fighting a lifelong rear-guard battle, grimly retreating toward early death or disability, your body can turn on a dime and win.
You can feel the difference in less than a month. My wife and I did—even after 55-plus years of media-complicit, ignorant, self-indulgent eating.
The up-front freedom from illness, and the potential savings over time as we sidestep the medical system, are real game-changers. We have begun to make financial decisions based on healthy longevity, not fear of disease.
Some of these changes include adjusting our investment risk tolerance, canceling or scaling back insurance plans, increasing deductibles, and even putting off Social Security…indefinitely.
We haven’t abandoned the basics of sound financial planning, and strongly recommend maintaining a substantial “rainy day” fund. Investments should be diverse and reflect your own specific risk tolerance. Liquidity should increase as you age. Remember, even the best diet and fabulous health don’t guarantee that you will be injury- or illness-free.
But what might our savings look like?
If we subtract the pure out-of pocket-costs for LTC, estimated savings could be approximately $220,000.00 from age 65 to end of life (or more, based on the worst case scenario above). Fidelity investments estimates NON-LTC costs at $280,000.00—and that includes “routine” care for things like diabetes and hypertension. [6]
Since we are on track to bypass most or all inflammation- and metabolic-related issues, expenses could be limited to premiums (and deductibles for non-chronic care). Putting a total savings of close to $300,000.00 within reach.
What would you be willing to change, to keep this kind of money in your pocket?
(Hint: start with your diet.)
About David Whiteside
David Whiteside spent 23 years as a professional insurance agent and financial advisor, including 9 years as a Medicaid case manager. He spent most of that time advising seniors and retirees on long-term health and monetary issues.
Unexpected, dramatic personal success on the Paleo diet (from 1/1/2016) spurred David to research and write on Paleo’s implications for healthy aging. He now devotes his time to promoting awareness of Paleo in the senior community.
David specializes in making science accessible to casual readers, including little-known or controversial ideas that repudiate conventional dietary advice. He blogs at www.Paleo55plus.com
View all posts by David Whiteside
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Remember those “learning to cook” days of uncomplicated meals such as chicken and tomato soup? The aromas, the straightforward ingredients and the effortless preparation that went into a comforting bowl of homemade goodness… Simple meals have a tendency to leave a lasting impression, and they do so with good reason. We love to go back to our favorites time and time again because they bring many happy memories along with them. And we have just made a new merry memory, involving chicken and a scrumptious tomato curry, that we would love to share with you.
We are leaving the fantasy and the fluff out – no bread here! – and simply calling this recipe: chicken with creamy tomato curry. If you are a lover of healing spices such as turmeric, cumin and garam masala, then you are going to adore this warming dish. It is perfectly well and good to use store-bought garam masala, yet if you want to up your game in the kitchen, it is to your advantage to create your own, using a mix of several herbs and spices. Recipes for garam masala are abound, be on the lookout!
If you are feeling particularly adventurous in cultivating your cooking skills, you may wish to adorn your steaming bowl of curry with something more than finely chopped cilantro, how about a generous dollop of homemade yogurt instead? There is a learning curve to overcome, but it is a tasty one. Once you master the art of handling live bacteria and probiotics, your gut will thank you for it.
Serves: 4Prep: 20 minCook: 30 min
Values are per portion. These are for information only & are not meant to be exact calculations.
P.S. Have a look at Paleo Restart, our 30-day program. It has the tools to let you reset your body, lose weight and start feeling great.
+ The Paleo Leap Meal Planner is now also available. Put your meal planning on autopilot!
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Grilled chicken can be decidedly plain, or it can be superior in both flavor and texture. Chances are good that you’ve experienced it both ways, but would choose the latter in a heartbeat. The secret to creating a grilled chicken masterpiece is to opt for the thighs, instead of the boneless chicken breast, and to create an enticing marinade with lime juice, coconut milk and a homemade curry paste. It never hurts to add in some minced ginger and garlic too, for some unexpected spicier notes.
Coconut and lime are typically the flavors of summer, though if you are grilling in winter, this may be a good reason to invoke sunnier memories with the flames of the grill. On the opposite end, there is also a cold weather favorite of ours, creamy coconut lime chicken soup, that keeps our spirits warm, and going strong, all winter long. Let’s just agree then that coconut and lime are crazy-compatible seasonings meant to enrich our lives the whole year through.
While we are onto the grilled coconut-lime topic, have you ever considered baking a platter of coconut-lime shrimp? It is a wonderful way to get out of a chicken rut, and an ingenious way to mix up seafood and poultry using like-minded ingredients. Maybe they would be scrumptious when served side by side in all their coconut and lime glory?
Serves: 4Prep: 15 min + 4 hCook: 20 min
Values are per portion. These are for information only & are not meant to be exact calculations.
P.S. Have a look at Paleo Restart, our 30-day program. It has the tools to let you reset your body, lose weight and start feeling great.
+ The Paleo Leap Meal Planner is now also available. Put your meal planning on autopilot!

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Victoria Thostrup
I was diagnosed with Fibromyalgia around 7 years ago although I’m certain I have had it much longer than that. I have suffered from sleeplessness, joint stiffness, severe pains, depression and fatigue. My neurologist prescribed duloxetin 40mg daily (Given as 20mg twice daily), although it did relieve some of the pain, I still suffered from joint stiffness and extreme fatigue. Finally, i started on Fibromyalgia herbal formula i ordered from Natural Herbal Gardens, this herbal formula did the magic! almost immediately i started usage, i started noticing a general reduction of symptoms including the very severe pains and fatigue. 9 weeks into usage, the disease has totally succumbed to this herbal treatment. The whole pains and terrible fatigue has seized and i am now able to function fully well again. (Visit www .naturalherbalgardens . com ) I’m able to get out of bed in the morning and have more energy to go about my daily activities.
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Today's weather is going to dictate what we get up to.
It's supposed to be wet, wet and even wetter. But hopefully not until later on in the day.
If it's not wet this morning I plan on jumping on an FBG walk. It's the first walk of the FINAL SECTIONS, out at St Kilda... which is a very nice suburb just out of town.
This section can be walked as one (about 11 kms), or split into two.
I am leading both separate sections next week in the evening.
But I would like to participate and do one half today. So, if it's 'on', I will go.
The other thing I might do today is start another, shorter in length table runner. In red and silver, cos I just loved how the big one came out!
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And in 2013 one of the world's pre-eminent scientific journals, Nature, took the extraordinary step of publicly rebuking Willett for over-simplifying research results, discarding data that didn't fit his views, and engaging in unseemly behavior towards people who venture conclusions different from him.
This is the behavior of a religious fanatic not a scientist. I am damn tired of these busybodies poking their noses into private lives. #yes2meat#ignorethedictocrats #no2dictocrats #nomeattax